https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47995 Wed 22 Mar 2023 15:56:37 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49464 Thu 18 May 2023 14:19:57 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53155 Vglut2+) to the medial insular cortex in this behavior. Whole brain activation mapping and hierarchical clustering of Euclidean distances revealed distinct patterns of coactivation unique to stress-induced binge eating. At a pathway-specific level, PVT^Vglut2+ cells projecting to the medial insular cortex were specifically activated in response to stress-induced binge eating. Subsequent chemogenetic inhibition of this pathway suppressed stress-induced binge eating. We have identified a distinct PVT^Vglut2+ to insular cortex projection as a key driver of "emotional" stress-induced binge eating in female mice, highlighting a novel circuit underpinning this sex-specific behavior.]]> Mon 27 Nov 2023 15:54:48 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42338 N = 29,125 cases and 34,836 controls), a robust polygenic signal was observed from gene sets based on TCF4, FMR1, upregulation from MIR137 and downregulation from CHD8. Additional analyses revealed a constant floor effect in the amount of variance explained, consistent with the omnigenic model. Thus, we report that putative core gene sets showed a significant effect above and beyond the floor effect that might be linked with the underlying omnigenic background. In addition, we demonstrate a method to quantify the contribution of specific gene sets within the omnigenic context.]]> Mon 22 Aug 2022 14:00:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50937 Mon 14 Aug 2023 12:58:13 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48732 Fri 31 Mar 2023 09:37:21 AEDT ]]>